According to http://neomam.com/blog/what-makes-an-infographic-bad-and-how-to-make-it-better/, and important thing to consider when creating an infographic is to leave some negative space, and not completely clutter your piece and covering the background. It says that allowing some of the background to show through helps the eye to organize the data presented. It is important to get this balance right though, as too much white space will leave the infographic looking unfinished.
The composition of the elements within the infographic should be balanced and aligned to allow the viewer to let their eyes take them through your information. When elements are messily arranged, it can be hard to know what to look at first.
This infographic shows some different layout styles when creating an infographic:
As my infographic compares two sides to a topic, I am drawn mostly to the comparison style. This source says that when comparing things in this way, the visuals have to be very strong, so that you get your point across – which is what I aim to do, particularly because I do not want to rely on text for people to understand the points I am trying to convey. This source also says that using a comparison layout works well if you have bullet-pointed information that you want to convey simply.